Bronchiectasis is a chronic pulmonary disorder in which the airways, or bronchi, become permanently dilated due to a vicious cycle of inflammation and complications from prior infections.1,2 Bronchiectasis is marked by frequent pulmonary exacerbations requiring antibiotic therapy and/or hospitalizations. Symptoms include chronic cough, excessive sputum production, shortness of breath, and repeated respiratory infections, which can worsen the underlying condition.1,2
There is a high overlap in patients with NTM lung disease and patients with bronchiectasis.2 Today, no therapies are approved specifically for the treatment of bronchiectasis in the U.S., EU, or Japan.
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- Prevalence and incidence of noncystic fibrosis bronchiectasis among US adults in 2013 (Weycker). https://www.ncbi.nlm.nih.gov/pubmed/28555504. Accessed December 2020.
- Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity (Flume). https://www.ncbi.nlm.nih.gov/pubmed/30215383. Accessed December 2020.